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KMID : 1143220180610040524
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Obstetrics & Gynecology Science
2018 Volume.61 No. 4 p.524 ~ p.528
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Primary malignant melanoma of the uterine cervix treated with pembrolizumab after radical surgery: a case report and literature review
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Kim Myeong-Seon
Choi Chel-Hun
Kim Tae-Joong
Lee Jeong-Won
Lee Jee-Yun
Bae Duk-Soo
Kim Byoung-Gie
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Abstract
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Malignant melanoma of the genital tract is a rare disease that is usually diagnosed by chance. When a definite diagnosis is delayed, the prognosis is very poor without standardized treatment. Herein, we describe a 40-year-old patient who presented with a history of bloody vaginal discharge for 7 months. Gynecological examination showed an exophytic, hard and pigmented cervical mass involving the upper vagina. The patient was diagnosed with cervical melanoma after a punch biopsy and underwent a radical hysterectomy, upper vaginectomy, bilateral salpingo-oophorectomy and pelvic lymphadenectomy. After surgeries, the patient underwent 2-cycles of adjuvant immunotherapy with pembrolizumab, but died within 8 months. In this report, treatment with pembrolizumab after radical surgery was not effective for this patient who had a primary cervical melanoma that metastasized to bone and lung tissue. We do not know why pembrolizumab was ineffective for this patient, but there are several possible explanations; further research is needed.
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KEYWORD
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Melanoma, Pembrolizumab, Antibodies, monoclonal, humanized, Uterine Cervical Neoplasms
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